Tc99m-renal imaging agent--the preparation and comparative clinical evaluation.

Radionuclide Tc99m DTPA (Diethylenetriaminepenta Acetic Acid) renal imaging is being used to assist in the evaluation of overall GFR, the intra-renal transit time, the cortical transit time, response to frusimide injection, diagnosis of ATN and rejection in renal transplant cases. A study was conducted at PINSTECH in order to prepare DTPA kit locally and evaluate the labeling efficiency as well as the in vitro and in vivo stability of Tc99m DTPA preparation. The results were comparable with those of imported Renal imaging (pentetate-II Technetium 99m) agent. The shelf life of the kit at room temperature recorded is around 3 months, the labeling efficiency with Tc99m pertechnetate is more than 99% and the fraction of hydrolyzed Tc99m recorded is less than 1%. On clinical trials no artifacts were seen on scintigraphic images.